Table 5.

The lists of overlapped binding proteins of Chinese herbal medicine (CHM) and western medicine (WM) for immune system-related proteins. The number of all binding proteins of CHM and WM clusters is presented as well (the detail binding proteins of each group are listed in the supplementary materials S4).

	Sympathomimetics (n = 55)	Antihistamines (n = 32)	LRA (n = 7)	Glucocorticoids (n = 29)
Cluster 1, wind-heat syndrome (n = 356)	FOS, COLI, TNFA, IL-8, and MIF	COLI, IL-8, and MMP9	IL-13	COLI and TNFA
Cluster 2, wind-cold-dampness syndrome (n = 480)	FOS, COLI, TNFA, IL-8, and MIF	COLI, IL-8, and MMP9	LOX5 and IL-13	COLI and TNFA
Cluster 3, wind syndrome (n = 152)	FOS, IL-8, and MIF	IL-8 and MMP9	—	—
Cluster 4, phlegm syndrome (n = 244)	FOS, TNFA, and IL-8	IL-8 and MMP9	—	TNFA
Cluster 5, heat-toxin syndrome (n = 104)	FOS and IL-8	IL-8 and MMP9	—	—
Cluster 6, Qi-stagnation syndrome (n = 326)	FOS, IL-8, and MIF	IL-6, IL-8, and MMP9	—	IL-6

∗LRA, leukotriene receptor antagonist.