Table 3.
Results of the mammalian erythrocyte micronucleus test for water-extract sericin.
| Groups | Number of mice examined | Number of PCE examined | Number of micronucleated PCE observed | Micronucleated PCE (‰) | Number of RBC examined | Number of PCE observed | PCE/RBC |
|---|---|---|---|---|---|---|---|
| Male | |||||||
| 6660 | 5 | 5 × 2000 | 13 | 1.3 ± 0.4 | 5 × 1000 | 232 | 4.64 ± 0.92 |
| 3330 | 5 | 5 × 2000 | 16 | 1.6 ± 0.7 | 5 × 1000 | 240 | 4.80 ± 1.17 |
| 1665 | 5 | 5 × 2000 | 15 | 1.5 ± 0.5 | 5 × 1000 | 237 | 4.74 ± 0.80 |
| Negative | 5 | 5 × 2000 | 15 | 1.5 ± 0.5 | 5 × 1000 | 223 | 4.46 ± 0.72 |
| Positive | 5 | 5 × 2000 | 219 | 21.9 ± 4.3∗∗ | 5 × 1000 | 156 | 3.12 ± 1.12 |
| Female | |||||||
| 6660 | 5 | 5 × 2000 | 14 | 1.4 ± 0.5 | 5 × 1000 | 226 | 4.52 ± 0.96 |
| 3330 | 5 | 5 × 2000 | 14 | 1.4 ± 0.8 | 5 × 1000 | 241 | 4.82 ± 1.02 |
| 1665 | 5 | 5 × 2000 | 15 | 1.5 ± 0.5 | 5 × 1000 | 224 | 4.48 ± 1.52 |
| Negative | 5 | 5 × 2000 | 14 | 1.4 ± 0.5 | 5 × 1000 | 229 | 4.58 ± 1.09 |
| Positive | 5 | 5 × 2000 | 213 | 21.3 ± 3.1∗∗ | 5 × 1000 | 164 | 3.28 ± 1.02 |
PCE: polychromatic erythrocyte; RBC: red blood cell. For micronucleated PCE and PCE/RBC, the data represent the mean ± standard deviation of 5 animals. ∗∗Significant difference compared to the control at p < 0.01.