Table 4.
Results of mouse spermatogonia chromosomal aberration test for sericin extract.
| Group (mg/kg) | Number of cells examined | Chromosomal number abnormality | Alteration of chromosomal structure | Number of cells with chromosomal aberration | Rate of cells with chromosomal aberration (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Aneuploid | Polyploid | Gaps | Breakage | Fragment | Microchromosome | Circular | Others | ||||
| 6660 (24 h) | 100 × 5 | 0 | 36 | 28 | 10 | 26 | 0 | 1 | 0 | 101 | 14.6 ± 1.7 |
| 6660 (48 h) | 100 × 5 | 0 | 36 | 22 | 10 | 24 | 1 | 0 | 0 | 93 | 14.2 ± 1.9 |
| 3330 | 100 × 5 | 0 | 33 | 23 | 10 | 23 | 0 | 1 | 0 | 90 | 13.4 ± 0.9 |
| 1665 | 100 × 5 | 0 | 35 | 32 | 12 | 12 | 1 | 1 | 0 | 93 | 12.2 ± 1.5 |
| Negative control | 100 × 5 | 0 | 37 | 20 | 11 | 24 | 1 | 1 | 0 | 92 | 14.4 ± 1.8 |
| Positive control | 100 × 5 | 0 | 37 | 47 | 99 | 164 | 2 | 7 | 0 | 356 | 61.8 ± 3.9∗∗ |
Rate of cells with chromosomal aberration (%) = (number of cells with chromosomal aberration − number of cells with chromosomal gaps)/number of cells examined × 100%.