(a).

Dose (mg/kg)	AST (U/L)	ALT (U/L)	BUN (mmol/L)	CR (μmol/L)	TC (mmol/L)	TG (mmol/L)	TP (g/L)
Male
1000	100.4 ± 9.9	42.5 ± 6.0	7.10 ± 0.64	34.6 ± 4.7	1.84 ± 0.3	0.82 ± 0.17	68.0 ± 2.5
500	105.8 ± 13.0	50.4 ± 4.8	7.09 ± 0.85	36.3 ± 4.6	1.76 ± 0.2	0.93 ± 0.19	67.7 ± 3.3
250	99.8 ± 12.0	45.4 ± 6.8	6.38 ± 0.68	33.7 ± 4.8	1.80 ± 0.3	0.85 ± 0.20	67.8 ± 3.6
Control	96.3 ± 10.4	46.3 ± 5.2	6.54 ± 0.57	34.9 ± 5.1	1.94 ± 0.2	0.98 ± 0.19	66.7 ± 2.5
Female
1000	91.3 ± 6.0	41.8 ± 3.5	6.93 ± 0.77	39.0 ± 5.9	1.98 ± 0.3	0.88 ± 0.14	74.6 ± 4.4
500	88.8 ± 7.4	43.3 ± 3.3	6.79 ± 0.66	40.0 ± 4.4	2.07 ± 0.4	0.91 ± 0.20	72.7 ± 4.2
250	95.2 ± 8.6	42.1 ± 6.0	6.94 ± 0.54	37.4 ± 5.8	2.09 ± 0.4	0.91 ± 0.27	75.9 ± 4.0
Control	90.1 ± 8.9	40.3 ± 5.4	6.66 ± 0.80	38.6 ± 5.2	2.22 ± 0.3	0.94 ± 0.25	73.2 ± 4.1