Table 1.

Effects of diabetes (DM) and/or estrogen deficiency on the body mass gain and the mass of selected internal organs in rats.

Parameter/group	Nonovariectomized (NOVX) rats		Ovariectomized (OVX) rats		Two-way ANOVA
	Control	DM	Control	DM	OVX	DM	OVXx DM
Initial body mass (g)&	226.9 ± 3.3	208.7 ± 3.7∗∗	220.9 ± 4.5	207.4 ± 3.7∗∗∗X	NS	p < 0.001	NS
4-week body mass gain (g)	12.1 ± 1.7	−17.4 ± 4.1∗∗∗	42.1 ± 5.2∗∗∗	−22.8 ± 5.6∗∗∗XXX	p < 0.01	p < 0.001	p < 0.001
Uterus mass (g)	0.511 ± 0.054	0.171 ± 0.030∗∗∗	0.096 ± 0.006∗∗∗	0.095 ± 0.007∗∗∗	p < 0.001	p < 0.001	p < 0.001
Thymus mass (g)	0.297 ± 0.019	0.093 ± 0.014∗∗∗	0.529 ± 0.030∗∗∗	0.056 ± 0.011∗∗∗XXX	p < 0.001	p < 0.001	p < 0.001
Liver mass (g)	5.656 ± 0.114	8.099 ± 0.329∗∗∗	6.197 ± 0.180	7.926 ± 0.299∗∗∗XXX	NS	p < 0.001	NS
Adrenals mass (g)	0.078 ± 0.004	0.071 ± 0.004	0.073 ± 0.004	0.059 ± 0.003∗∗∗XX a	p < 0.05	p < 0.01	NS

Bilateral ovariectomy was performed 5 weeks before the end of the experiment. Diabetes was induced 3 days after the ovariectomy by a single administration of streptozotocin (60 mg/kg i.p.). Results are presented as means ± SEM (n = 9 − 10). Two-way ANOVA followed by Fisher's LSD test was used for evaluation of the significance of the results. ^&Body mass one week after the ovariectomy; ^∗∗p < 0.01, ^∗∗∗p < 0.001—significantly different from the NOVX control rats; ^Xp < 0.05, ^XXp < 0.01, ^XXXp < 0.001—significantly different from the OVX control rats; ^ap < 0.05—significantly different from the DM-NOVX rats.