Table 2.
Effects of diabetes (DM) and/or estrogen deficiency on the serum metabolic parameters and calcium and phosphorus concentrations.
| Parameter/group | Nonovariectomized (NOVX) rats | Ovariectomized (OVX) rats | Two-way ANOVA | ||||
|---|---|---|---|---|---|---|---|
| Control | DM | Control | DM | OVX | DM | OVXx DM | |
| Glucose (mg/100 mL) | 82.8 ± 2.7 | 561.4 ± 12.2∗∗∗ | 82.9 ± 1.5 | 575.9 ± 12.5∗∗∗XXX | NS | p < 0.001 | NS |
| Fructosamine (mM/L) | 0.483 ± 0.010 | 1.106 ± 0.051∗∗∗ | 0.491 ± 0.014 | 0.887 ± 0.111∗∗∗XXX a | NS | p < 0.001 | NS |
| Triglycerides (mg/100 mL) | 35.8 ± 3.8 | 68.8 ± 7.3∗∗ | 40.8 ± 2.2 | 89.1 ± 11.4∗∗∗XXX | NS | p < 0.001 | NS |
| Cholesterol (mg/100 mL) | 47.5 ± 4.9 | 53.3 ± 3.1 | 65.7 ± 2.4∗∗∗ | 69.8 ± 2.4∗∗∗aa | p < 0.001 | NS | NS |
| LDL cholesterol (mg/100 mL) | 25.0 ± 3.8 | 31.4 ± 4.5 | 49.6 ± 6.1∗∗∗ | 34.4 ± 3.9X | p < 0.01 | NS | p < 0.05 |
| HDL cholesterol (mg/100 mL) | 28.4 ± 2.0 | 30.8 ± 1.3 | 24.2 ± 0.5 | 34.2 ± 3.3XX | NS | p < 0.01 | NS |
| AOPP (μmol/L)& | 14.3 ± 1.4 | 17.2 ± 1.3 | 15.6 ± 1.5 | 23.2 ± 3.3∗∗X | NS | p < 0.05 | NS |
| Calcium (mg/100 mL) | 9.97 ± 0.23 | 11.51 ± 0.25∗∗∗ | 9.82 ± 0.27 | 11.86 ± 0.32∗∗∗XXX | NS | p < 0.001 | NS |
| Inorganic phosphorus (mg/100 mL) | 8.51 ± 0.48 | 4.98 ± 0.58∗∗∗ | 9.40 ± 0.51 | 6.38 ± 0.62∗∗XXX | p < 0.05 | p < 0.001 | NS |
Bilateral ovariectomy was performed 5 weeks before the end of the experiment. Diabetes was induced 3 days after the ovariectomy by a single administration of streptozotocin (60 mg/kg i.p.). Results are presented as means ± SEM (n = 9 − 10). &The concentration of AOPP is presented in chloramine T equivalents. Two-way ANOVA followed by Fisher's LSD test was used for evaluation of the significance of the results. ∗∗p < 0.01, ∗∗∗p < 0.001—significantly different from the NOVX control rats; Xp < 0.05, XXp < 0.01, XXXp < 0.001—significantly different from the OVX control rats; ap < 0.05, aap < 0.01—significantly different from the DM-NOVX rats.