Table 4.
Effects of diabetes (DM) and/or estrogen deficiency on the histomorphometric parameters of compact bone of the femoral diaphysis in rats.
| Parameter/group | Nonovariectomized (NOVX) rats | Ovariectomized (OVX) rats | Two-way ANOVA | |||||
|---|---|---|---|---|---|---|---|---|
| Control | DM | Control | DM | OVX | DM | OVXx DM | ||
| Diaphysis | Tt.Ar (mm2) | 8.21 ± 0.11 | 7.81 ± 0.16 | 8.39 ± 0.18 | 7.79 ± 0.13XX | NS | p < 0.01 | NS |
| Ct.Ar (mm2) | 5.42 ± 0.06 | 5.10 ± 0.08∗∗ | 5.51 ± 0.08 | 5.02 ± 0.05∗∗∗XXX | NS | p < 0.001 | NS | |
| Ma.Ar (mm2) | 2.79 ± 0.07 | 2.70 ± 0.11 | 2.87 ± 0.13 | 2.78 ± 0.10 | NS | NS | NS | |
| Ma.Ar/Tt.Ar | 0.340 ± 0.005 | 0.346 ± 0.008 | 0.341 ± 0.009 | 0.355 ± 0.007 | NS | NS | NS | |
Bilateral ovariectomy was performed 5 weeks before the end of the experiment. Diabetes was induced 3 days after the ovariectomy by a single administration of streptozotocin (60 mg/kg i.p.). Results are presented as means ± SEM (n = 9 − 10). Two-way ANOVA followed by Fisher's LSD test was used for evaluation of the significance of the results. ∗∗p < 0.01, ∗∗∗p < 0.001—significantly different from the NOVX control rats; XXp < 0.01, XXXp < 0.001—significantly different from the OVX control rats; Tt.Ar: transverse cross-section area of the whole diaphysis; Ct.Ar: transverse cross-section area of the cortical bone; Ma.Ar: transverse cross-section area of the marrow cavity; Ma.Ar/Tt.Ar: transverse cross-section area of the marrow cavity/diaphysis ratio.