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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Adv Healthc Mater. 2020 Sep 23;9(21):e2000880. doi: 10.1002/adhm.202000880

Figure 4.

Figure 4.

Characterizations of MSC-derived CAF and its influence on cancer cell growth when cocultured in L-TumorChip. (A) Representative images of differentiated cells stained with the CAF-specific biomarkers (CD31 used as a negative control here). (B) Flow cytometry analysis on FAP/α-SMA expressions in MSC and the derived CAF. Results are represented as average ± S.D. (n = 3). Significance was determined using Student t-test (*, p < 0.05). (C) The proliferation and (D) doubling time of GFP-expressing MDA-MB-231 under different tumor microenvironment conditions in the device. Results are represented as average ± S.D. (n = 4). Significance was determined using one-way ANOVA and Tukey’s Multiple Comparison Test (*, p < 0.05; ***, p < 0.001).