Table 4.

Univariate analysis of factors associated with survival after first pulmonary metastasectomy (PM)

Variables	Univariate
	HR	95% CI	p value
Female sex	0.98	0.62–1.55	0.93
Age < 70 years	1.14	0.63–2.05	0.66
Colorectal tumor	0.56	0.33–0.95	0.03*
Previous extra-thoracic metastases	1.19	0.74–1.90	0.48
Chemotherapy before first PM	1.21	0.77–1.91	0.41
DFI1 < 12 months	1.48	0.89–2.45	0.13
Metachronous metastases	0.48	0.25–0.95	0.04*
Solitary pulmonary metastasis	0.74	0.47–1.17	0.20
Unilateral pulmonary metastasis	0.81	0.48–1.34	0.41
VATS	0.75	0.46–1.23	0.26
Wedge resection	1.27	0.67–2.41	0.47
Margins of the pulmonary metastasis < 5 mm	1.14	0.72–1.81	0.56
Size of the largest pulmonary metastasis < 20 mm	0.97	0.53–1.76	0.92
Mediastinal lymph nodes involvement	1.68	0.61–4.64	0.32
RPM	0.50	0.28–0.87	0.02*

HR hazard ratio; CI confidence interval; PM pulmonary metastasectomy; DFI1 disease-free interval between primary tumour resection and first pulmonary metastasectomy; VATS Video-Assisted Thoracic Surgery; RPM: repeated pulmonary metastasectomy