Table 1.
Sample and medical characteristics by FKBP5 rs1360780 genotype
| Total sample | FKBP5 rs1360780 genotype | p1 | |||
|---|---|---|---|---|---|
| N = 268 (100%) | CC n = 141 (52.6%) |
CT n = 111 (41.4%) |
TT n = 16 (6.0%) |
||
| Demographics | |||||
| Age M ± SD | 63.49 ± 10.21 | 63.79 ± 10.33 | 63.40 ± 9.94 | 61.50 ± 11.31 | 0.464 |
| Male n (%) | 217 (81.0) | 117 (83.0) | 88 (79.3) | 12 (75.0) | 0.333 |
| Charlson Comorbidity Index (CCI)2 M ± SD | 0.81 ± 1.23 | 0.84 ± 1.20 | 0.82 ± 1.32 | 0.38 ± 0.89 | 0.318 |
| Coronary heart disease (CHD) characteristics | |||||
| Prior MI/coronary revascularization n (%) | 172 (64.2) | 93 (66.0) | 68 (61.3) | 11 (68.8) | 0.709 |
| Acute coronary syndrome at baseline n (%) | 119 (44.4) | 60 (42.6) | 53 (47.7) | 6 (37.5) | 0.761 |
| Left ventricular ejection fraction (%) M ± SD | 48.39 ± 14.12 | 48.25 ± 14.02 | 48.81 ± 14.47 | 46.74 ± 14.39 | 0.964 |
| CHD risk factors | |||||
| Current smoking n (%) | 70 (26.1) | 39 (27.7) | 28 (25.2) | 3 (18.8) | 0.443 |
| Diabetes n (%) | 72 (26.9) | 37 (26.2) | 29 (26.1) | 6 (37.5) | 0.558 |
| Body mass index (kg/m2) M ± SD | 28.36 ± 5.02 | 28.02 ± 4.81 | 28.39 ± 4.89 | 31.19 ± 6.85 | 0.059 |
| Dyslipidemia n (%) | 191 (71.3) | 108 (76.6) | 75 (67.6) | 8 (50.0) | 0.016 |
| Antidepressive treatment | |||||
| Baseline n (%) | 13 (4.9) | 4 (2.8) | 7 (6.3) | 2 (12.5) | 0.063 |
| 1-month n (%) | 12 (4.5) | 5 (3.5) | 6 (5.4) | 1 (6.3) | 0.439 |
| 6-months n (%) | 13 (4.9) | 4 (2.8) | 8 (7.2) | 1 (6.3) | 0.157 |
| 12-months n (%) | 16 (6.0) | 8 (5.7) | 8 (7.2) | – | 0.819 |
P-values < 0.05 were considered statistically significant and are shown in bold
M mean, SD standard deviation, MI myocardial infarction
1We used an additive model with the three genotypes coding as 0 (TT), 1 (CT), or 2 (CC) according to the number of C alleles
2We used a modified CCI (excluded were cardiac diagnoses and diabetes)
The variable ‘prior MI/coronary revascularization’ includes MI, percutaneous coronary intervention, and coronary artery bypass grafting before study inclusion. For analyzing categorical data, logistic regression and for analyzing continuous variables, linear regression was used. FKBP5 rs1360780 genotype was significantly associated with dyslipidemia