Table 2.
Immunohistochemical staining results of neuroendocrine markers among neuroendocrine and non-neuroendocrine neoplasms
| IHC staining outcome | IHC staining outcome | ||||||
|---|---|---|---|---|---|---|---|
| Chromogranin A (CGA) | Positive/Focally positive | Negative | Fisher's Exact P | Synaptophysin (SYP) | Positive/Focally positive | Negative | Fisher's Exact P |
| NENs (n=136) | 121 | 15 | <0.0001* | NENs (n=132) | 132 | 0 | <0.0001* |
| Non-NENs (n=20) | 3 | 17 | Non-NENs (n=19) | 8 | 11 | ||
| IHC staining outcome | IHC staining outcome | ||||||
| ISLET1 (ISL1) | Positive/Focally positive | Negative | Fisher's Exact P | INSM1 | Positive/Focally positive | Negative | Fisher's Exact P |
| NENs (n=139) | 91 | 48 | 0.0009* | NENs (n=85) | 76 | 9 | 0.0007* |
| Non-NENs (n=22) | 6 | 16 | Non-NENs (n=7) | 2 | 5 | ||
| IHC staining outcome | |||||||
| Secretagogin (SECG) | Positive/Focally positive | Negative | Fisher's Exact P | ||||
| NENs (n=64) | 49 | 15 | 0.0014* | ||||
| Non-NENs (n=5) | 0 | 5 |
IHC, immunohistochemistry; NENs, neuroendocrine neoplasms; Non-NENs, non-neuroendocrine neoplasms
*Fisher’s exact P considered significant at P < 0.05