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Sensitivity, specificity, and predictive values of the neuroendocrine markers to distinguish NENs from non-NENs
| IHC marker | Sensitivity | Specificity | Positive predictive value | Negative predictive value |
|---|---|---|---|---|
| Chromogranin A | 89% | 85% | 98% | 53% |
| Synaptophysin | 100% | 58% | 94% | 100% |
| ISL1 | 65% | 73% | 94% | 25% |
| INSM1 | 89% | 71% | 97% | 36% |
| Secretagogin | 77% | 100% | 100% | 25% |
IHC, immunohistochemistry; NEN, neuroendocrine neoplasia; non-NEN, non-neuroendocrine neoplasia
