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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Curr Opin Struct Biol. 2020 Jun 27;64:26–33. doi: 10.1016/j.sbi.2020.05.009

Table 1.

List of small membrane protein structures determined by cryo-EM.

Protein Organism Resolution PDB ID Year Sample condition MW of particles Protein components in the particles Reference
Hedgedog receptor Patched 1 (Ptch1) Homo sapiens 3.5 Å 6OEU 2018 Digitonin 163 kDa 160.5kDa [76]
Hedgedog receptor Patched 1 (Ptch1) Homo sapiens 3.9 Å 6DMB 2018 Digitonin 153 kDa Ptch1 160.5kDa [77]
ABC exporter Rv1819c Mycobacterium tuberculosis 3.5 Å 6TQF 2020 DDM 151 kDa Rv1819c 143kDa [75]
ABC exporter TrmAB Thermus thermophilus 2.8 Å 6RAH 2019 Nanodiscs 151 kDa TrmAB 133kDa [33]
Otopetrin (Otop3) Xenopus tropicalis 3.9 Å 6O84 2019 DDM, CHS 147 kDa Otop3 154kDa [78]
Hedgedog receptor Patched 1 (Ptch1) Mus musculus 3.6 Å 6MG8 2018 Amphipol 146 kDa Ptch1 159kDa [79]
ABCG2 Homo sapiens 3.1 Å 6HBU 2018 Nanodiscs 146 kDa ABCG2 144kDa [80]
Urea channel of Helicobacter pylori (HpUreI) Helicobacter pylori 2.7 Å 6NSJ 2019 Amphipol 146 kDa HpUreI 130kDa [22]
Glutamate transporter homologue GltTK Thermococcus kodakarensis 3.2Å 6XWR 2020 Nanodiscs 137 kDa GltTK 135kDa [30]
Otopetrin (Otop1) Danio rerio 3.0 Å 6NF4 2019 Nanodiscs 135 kDa Otop1 131kDa [31]
L-type amino acid transporter (LAT1–4F2hc complex) Homo sapiens 3.3 Å 6IRS 2019 Digitonin 131 kDa LAT1 55kDa; 4F2hc 68kDa [81]
GPR52-mini-Gs Homo sapiens 3.3 Å 6LI3 2020 LMNG, CHS 130 kDa GPR52 41kDa; mini-Gαs;Gβ1;Gγ2;Nb35 [63]
Otopetrin (Otop3) Gallus gallus 3.3 Å 6NF6 2019 Nanodiscs 129 kDa Otop3 135kDa [31]
Dolichyl pyrophosphate Man9GlcNAc2 α - 1,3- Glucosyltransferase (ALG6) Saccharomyces cerevisiae 3.0 Å 6SNI 2020 Nanodiscs 118 kDa ALG6 64kDa; 6AG9-Fab [35]
Cytochrome bd-I oxidase Escherichia coli 2.7 Å 6RKO 2019 Nanodiscs 114 kDa Cytochrome bd-I Oxidase 108kDa [34]
Serotonin transporter (SERT) Homo sapiens 4.1 Å 6DZY 2019 DDM, CHS 113 kDa SERT 70kDa; 15B8 Fab-8B6 scFv [46]
Plasmodium falciparum Chloroquine resistance transporter (PfCRT) 7G8 isoform Plasmodium falciparum 3.2 Å 6UKJ 2019 Nanodiscs 103 kDa PfCRT 49kDa; CDC-Fab [32]
Stimulator of interferon genes (STING) Homo sapiens 4.1 Å 6NT5 2019 DDM, CHS 86kDa STING alone [73]
Neurotensin Receptor and arrestin 1 complex (NSTR1-βarr1) Homo sapiens 4.2 Å 6UP7 2020 LMNG, CHS 79kDa NSTR1 47kDa; βarr1 47kDa; [67]