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Summary of drugs targeting S1P signaling.
| S1PR modulator | Molecular target | Phase of clinical trial |
|---|---|---|
| Fingolimod | S1P1, S1P3, S1P4, S1P5 | Approved for RRMS Phase III for PPMS |
| Siponimod | S1P1, S1P5 | Phase III for SPMS Phase I for RRMS |
| Amiselimod | S1P1, S1P4, S1P5 | Phase II for RRMS |
| Ceralifimod | S1P1, S1P5 | Phase II for RRMS |
| Ozanimod | S1P1, S1P5 | Phase III for RRMS |
| CS-0777 | S1P1 | Phase I for MS |
| Ponesimod | S1P1 | Phase III for RRMS |
