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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Am J Transplant. 2020 Jun 11;21(1):73–86. doi: 10.1111/ajt.16004

Figure 2. CTLA-4 blockade augments the follicular T cell and GC B cell alloresponses.

Figure 2.

(A) Naïve B6 mice were transplanted BALB/c skin, either left untreated or treated with anti-CTLA-4 mAb every other day (QOD, red), and graft-DLNs examined 10 days posttransplant. (B) Representative flow plots displaying the frequencies of Tfh cells and summary data of the frequencies and numbers of Tfh cells (n=5 per group). (C) Summary data of the frequencies and numbers of Treg and Tfr cells (n=5 per group). (D) Representative flow plots displaying the frequencies of GC B cells (GL7+CD95+, gated on IgD−CD19+B220+CD138− B cells) from untreated and anti-CTLA-4-treated mice and summary data of the frequencies and numbers GC B cells (n=5 per group). Summary data represent mean (SE). **p < 0.01.