Table 1 -.
Baseline characteristics of SPRINT participants by randomization arm
| Characteristic | Intensive (N=4678) | Standard (N=4683) | P-value† |
|---|---|---|---|
| Inclusion criteria – no. (%) | |||
| Age ≥75 years | 1317 (28.2) | 1319 (28.2) | 0.99 |
| Chronic kidney disease† | 1329 (28.4) | 1316 (28.1) | 0.74 |
| Cardiovascular disease | 940 (20.1) | 937 (20.0) | 0.92 |
| Clinical | 779 (16.7) | 783 (16.7) | 0.93 |
| Subclinical | 247 (5.3) | 246 (5.3) | 0.95 |
| Framingham 10-year cardiovascular disease risk score ≥15% | 3556 (76.0) | 3547 (75.7) | 0.76 |
| Female – no. (%) | 1684 (36.0) | 1648 (35.2) | 0.41 |
| Age – years | 67.9±9.4 | 67.9±9.5 | 0.82 |
| Age among those ≥75 years – years | 79.8±3.9 | 79.9±4.1 | 0.72 |
| Race/ethnicity‡ – no. (%) | |||
| African American | 1379 (29.5) | 1423 (30.4) | 0.33 |
| Hispanic | 503 (10.8) | 481 (10.3) | |
| European American | 2698 (57.7) | 2701 (57.7) | |
| Other | 98 (2.1) | 78 (1.7) | |
| African American‡ – no. (%) | 1454 (31.1) | 1493 (31.9) | 0.40 |
| Baseline blood pressure – mm Hg | |||
| Systolic | 139.7±15.8 | 139.7±15.4 | 0.96 |
| Diastolic | 78.2±11.9 | 78.0±12.0 | 0.45 |
| Systolic blood pressure tertiles – no. (%) | |||
| Systolic blood pressure ≤ 132 mm Hg | 1583 (33.8) | 1553 (33.2) | 0.95 |
| 132 mm Hg < Systolic blood pressure < 145 mm Hg | 1489 (31.8) | 1549 (33.1) | |
| Systolic blood pressure ≥ 145 mm Hg | 1606 (34.3) | 1581 (33.8) | |
| Serum creatinine – mg/dL | 1.07±0.34 | 1.08±0.34 | 0.22 |
| Estimated glomerular filtration rate – ml/min/1.73m2 | |||
| Overall | 71.8±20.7 | 71.7±20.5 | 0.88 |
| Estimated glomerular filtration rate ≥ 60 ml/min/1.73m2 | 81.3±15.5 | 81.1±15.5 | 0.50 |
| Estimated glomerular filtration rate < 60 ml/min/1.73m2 | 47.8±9.5 | 47.9±9.5 | 0.88 |
| Urine albumin/creatinine – mg/g | 44.1±178.7 | 41.1±152.9 | 0.43 |
| Total cholesterol – mg/dL | 190.2±41.4 | 190.0±40.9 | 0.98 |
| Fasting high density lipoprotein cholesterol – mg/dL | 52.9±14.3 | 52.8±14.6 | 0.44 |
| Fasting total triglycerides – mg/dL | 124.8±85.8 | 127.1±95.0 | 0.52 |
| Fasting plasma glucose – mg/dL | 98.8±13.7 | 98.8±13.4 | 0.74 |
| Statin use – no. (%) | 1978/4646 (42.6) | 2076/4640 (44.7) | 0.04 |
| Aspirin use – no. (%) | 2406/4662 (51.6) | 2350/4666 (50.4) | 0.23 |
| Smoking – no. (%) | |||
| Never smoker | 2051 (43.8) | 2072 (44.2) | 0.51 |
| Former smoker | 1977 (42.3) | 1996 (42.6) | |
| Current smoker | 639 (13.7) | 601 (12.8) | |
| Missing | 11 (0.2) | 14 (0.3) | |
| Framingham 10-year cardiovascular disease risk score – % | 24.8±12.6 | 24.8±12.5 | 0.82 |
| Body mass index – kg/m2 | 29.9±5.8 | 29.8±5.7 | 0.61 |
| Antihypertension agents – count | 1.8±1.0 | 1.8±1.0 | 0.54 |
| Not using antihypertension agents – n (%) | 432 (9.2) | 450 (9.6) | 0.54 |
†
P-values were computed using Wilcoxon rank sum test and chi square tests for contingency tables. The Mantel-Haenszel chi square test for ordered alternatives was used for systolic blood pressure tertiles.
‡
Race/ethnic was self-reported. African American race includes Hispanic ethnicity reporting African ancestry, African American, and African American as part of a multiracial identification.