Table 2 –

Number of non-primary SPRINT outcome hospitalizations by randomized arm and pre-specified SPRINT subgroups^*

SPRINT group	Intensive arm			Standard arm			p-value†
	Number of hospitalizations	Number of person years	Hospitalizations per 100 person years	Number of hospitalizetions	Number of person years	Hospitalizations per 100 person years
Overall	2907	14756.2	19.70	2887	14688.8	19.65	0.37
Previous CKD
Yes	1133	4229.2	26.79	1197	4161.0	28.77	0.34
No	1774	10526.9	16.85	1690	10527.9	16.05	0.06
Age
< 75 years	1861	10774.2	17.27	1721	10749.0	16.01	0.11
>= 75 years	1046	3981.9	26.27	1166	3939.8	29.60	0.59
Sex
Male	1878	9393.5	19.99	1929	9463.1	20.38	0.90
Female	1029	5362.6	19.19	958	5225.7	18.33	0.16
Race
African American	840	4524.4	18.57	956	4646.7	20.57	0.31
Non-African American	2067	10231.7	20.20	1931	10042.1	19.23	0.08
Hispanic	168	1380.6	12.17	120	1344.2	8.93	0.01
European American	1864	8565.4	21.76	1787	8511.9	20.99	0.25
Other	35	285.6	12.25	24	186.0	12.90	0.38
Previous CV disease
Yes	879	2931.0	29.99	892	2871.3	31.07	0.89
No	2028	11825.1	17.15	1995	11817.5	16.88	0.25
Systolic BP
<=132 mm Hg	972	5038.0	19.29	949	4841.3	19.60	0.89
> 132 to < 145 mmHg	966	4714.9	20.49	874	4892.7	17.86	0.03
>= 145 mm Hg	969	5003.2	19.37	1064	4954.8	21.47	0.52

^*Excludes hospitalizations linked to a primary SPRINT outcome. These primary SPRINT outcome events include the first occurrence of myocardial infarction, stroke, heart failure, or non-MI acute coronary syndrome.

^†P-values computed using the Tweedie distribution; analyses were repeated with the gamma distribution which yielded similar results.

There was no evidence of a difference in secondary event hospitalization rates after adjusting for age, gender, ethnicity, previous CKD, previous CVD, and systolic blood pressure (p=0.27).

Formal test of interaction with the treatment arm p-value: Previous CKD p=0.058; Age p=0.157; Sex p=0.294; Race p=0.219; Previous CV disease p=0.469; Systolic BP p=0.564.