Table 3 –
Primary Events and non-SPRINT primary outcome hospitalizations by ICD-10 categories
| SPRINT group | Intensive arm | Standard arm | |||
|---|---|---|---|---|---|
| Number of Events | Events per 100 person years† | Number of Events | Events per 100 person years† | P-value** | |
| All primary events* | 369 | 2.50 | 498 | 3.39 | 0.0006 |
| G00-G99 Diseases of the nervous system - adjudicated | 73 | 0.49 | 83 | 0.57 | 0.72 |
| I00-I99 Diseases of the circulatory system - adjudicated | 296 | 2.01 | 415 | 2.83 | 0.0002 |
| Number of Hospitalizations | Hospitalizations per 100 person years† | Number of Hospitalizations | Hospitalizations per 100 person years† | p-value | |
| All hospitalizations not tied to primary events | 2907 | 19.70 | 2887 | 19.65 | 0.37 |
| A00-B99 Certain infectious and parasitic diseases | 370 | 2.51 | 327 | 2.23 | 0.19 |
| C00-D49 Neoplasms | 94 | 0.64 | 150 | 1.02 | 0.41 |
| D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | 34 | 0.23 | 43 | 0.29 | 0.99 |
| E00-E89 Endocrine, nutritional and metabolic diseases | 133 | 0.90 | 107 | 0.73 | 0.11 |
| F01-F99 Mental, Behavioral and Neurodevelopmental disorders | 87 | 0.59 | 61 | 0.42 | 0.02 |
| G00-G99 Diseases of the nervous system - not adjudicated | 338 | 2.29 | 283 | 1.93 | 0.01 |
| H00-H59 Diseases of the eye and adnexa | 6 | 0.04 | 9 | 0.06 | ‡ |
| H60-H95 Diseases of the ear and mastoid process | 22 | 0.15 | 19 | 0.13 | 0.57 |
| I00-I99 Diseases of the circulatory system - not adjudicated | 640 | 4.34 | 730 | 4.97 | 0.10 |
| J00-J99 Diseases of the respiratory system | 157 | 1.06 | 188 | 1.28 | 0.39 |
| K00-K95 Diseases of the digestive system | 303 | 2.05 | 309 | 2.10 | 0.77 |
| L00-L99 Diseases of the skin and subcutaneous tissue | 10 | 0.07 | 2 | 0.01 | ‡ |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | 57 | 0.39 | 63 | 0.43 | 0.74 |
| N00-N99 Diseases of the genitourinary system | 169 | 1.15 | 163 | 1.11 | 0.78 |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | 7 | 0.05 | 5 | 0.03 | 0.62 |
| S00-T88 Injury, poisoning and certain other consequences of external causes | 480 | 3.25 | 428 | 2.91 | 0.27 |
| V00-Y99 External causes of morbidity such as accidents and falls | 0 | - | 0 | - | - |
Primary events, as specified in SPRINT, included a composite of cardiovascular death or first occurrence of myocardial infarction, stroke, heart failure, or non-MI acute coronary syndrome
Number of person years was 14,756.2 for the intensive arm, and 14,688.8 for the standard arm.
Model failed to converge due to low numbers.
Note: Columns will not sum to total hospitalizations because all primary events are counted and there were instances with >1 primary event per day; in addition, some primary events did not map to a hospitalization.
After adjustment for multiple comparisons by the Bonferroni correction (p=0.0028), none of the ICD-10 categories were more common in either the intensive or randomized arms of the trial.
CKD – chronic kidney disease; CV – cardiovascular; BP blood pressure