. Author manuscript; available in PMC: 2021 Jul 28.

Published in final edited form as: Hum Hered. 2020 Jul 28;84(6):256–271. doi: 10.1159/000508558

Table 2:

Smallest Risk Allele Frequency (RAF) with at Least 80% Power to Detect an Odds Ratio of 1.5 for a 1:1 Case Control Study with a Total of N Subjects, at 5 × 10⁻⁸ Significance Level

		True Mode of Genetic Susceptibility
N	Model Coding	Dominant	Additive	Recessive
5,000	Dominant	0.145	0.120	-
	Additive	0.170	0.115	0.655
	Recessive	-	0.310	0.515
	2df	0.165	0.125	0.550
20,000	Dominant	0.030	0.030	-
	Additive	0.030	0.030	0.335
	Recessive	-	0.130	0.230
	2df	0.030	0.030	0.240