Table 3.
Demonstrated substrate promiscuity of terpene cyclases with native, chemoenzymatically, and synthetically accessible elongated prenyl diphosphates.
| Enzyme (organism) | Native Substrates | Non-Native Substrates | New-to-Nature Products | Reference |
|---|---|---|---|---|
| amorpha-4,11-diene synthase (Artemisia annua) | 5 | 57, 58 | 94 | [137] |
| 5-epi-aristolochene synthase (Nicotiana tabacum) | 5 | 59 | 95 | [132] |
| aristolochene synthase (Penicillium roqueforti) | 5 | 56, 57 | 94 | [136] |
| cineol synthase (Salvia fruticosa) | 3 | 4 | - | [128] |
| δ-selinene synthase (Abies grandis) | 5 | 3 | - | [121] |
| γ-humulene synthase (Abies grandis) | 5 | 3 | - | [121] |
| limonene synthase (Citrus limon) | 3 | 4 | - | [128] |
| camphene synthase (Solanum elaeagnifolium) | 3 | 4 | - | [128] |
| sabinene synthase (Salvia pomifera) | 3 | 4 | - | [128] |
| TPS5 (Medicago truncatula) | 5 | 6 | - | [130] |
| δ-cadinene synthase (Gossypium arboreum) | 5 | 46, 47 | 81–85 | [133] |
| germacradien-4-ol synthase (Streptomyces citricolor) | 5 | 56, 57 | 94 | [136] |
| (+)-zizaene synthase (Chrysopogon zizanioides) | 5 | 3, 4, 6, 7 | - | [129] |
| germacerene D synthase | 5 | 45–50, 52–54 | 87–93 | [134] |
| (E)-β-farnesene synthase (Mentha × piperita) | 5 | 56 | 94 | [136] |
| R-germacene A synthase (Solidago canadensis) | 5 | 56, 57 | 94 | [136] |