Table 4:

Comparing Diagnostic Yield of stress MPI using Different Definitions for a Positive Test Result

	Abnormal MPI			Obstructive CAD*
	PET	SPECT	p-value	PET	SPECT	p-value
Abnormal PET MPI: SDS >2 or LVEF Reserve ≤ 0; Abnormal SPECT MPI: SDS >2 or post- stress LVEF ≤ 45% for SPECT	201/551 (36.5%)	87/671 (13.0%)	<0.001	47/551 (8.5%)	5/671 (0.7%)	<0.001
Abnormal perfusion (SSS ≥3)	151/640 (23.6%)	98/687 (14.0%)	<0.001	46/640 (7.2%)	6/687 (0.9%)	<0.001
Any ischemia (SDS >2)	125/640 (19.5%)	66/687 (9.6%)	<0.001	46/640 (7.2%)	4/687 (0.6%)	<0.001
Significant ischemia (SDS >7)	53/640 (8.3%)	18/687 (2.6%)	<0.001	34/640 (5.3%)	2/687 (0.3%)	<0.001
Any fixed defect (SRS >0)	94/640 (14.7%)	78/687 (11.4%)	0.07	17/640 (2.7%)	4/687 (0.6%)	0.002
Abnormal PET: LVEF Reserve ≤ 0 Abnormal SPECT: post-stress LVEF ≤ 45%	118/551 (21.4%)	32/671 (4.8%)	<0.001	21/551 (3.8%)	3/671 (0.4%)	<0.001
Global MFR ≤ 1.8	225/554 (40.6%)	---	---	30/554 (5.4%)	---	---

PET = positron emission tomography, SPECT = single photon emission computed tomography, SSS = summed stress score, SDS = summed difference score, SRS = summed rest score, MFR = myocardial flow reserve, LVEF = left ventricular ejection fraction

^*Numerator is the number of patients with obstructive CAD among those with an abnormal MPI and referred to a coronary angiogram.