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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Comp Neurol. 2020 Jun 1;529(2):281–295. doi: 10.1002/cne.24946

Figure 7: Reconstruction examples depicting the effect of the smoothness prior.

Figure 7:

When the Nissl stack (c) has missing or noisy sections, reconstruction to the next-best Nissl section contains small distortion accumulations (a). Inclusion of a smoothness constraint corrects this error (b). Additionally, highly damaged Nissl stacks can still be reconstructed despite major differences between damaged Nissl sections to corresponding MRI sections. For instance, ex-vivo MRI of a particular subject marmoset brain prior to sectioning (d) and successful Nissl reconstruction of the same marmoset brain despite major damage caused by sectioning process (e).