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. Author manuscript; available in PMC: 2021 Nov 11.
Published in final edited form as: Cell Host Microbe. 2020 Aug 11;28(5):699–711.e7. doi: 10.1016/j.chom.2020.07.008

Figure 1. Antibodies Generated from Donors Naturally Infected with RRV or CHIKV Bind and Neutralize RRV, MAYV, CHIKV, SAGV, GETV, and ONNV.

Figure 1.

(A and B) (A) Binding or (B) neutralization profiles of three broadly neutralizing mAbs, as determined through ELISA or FRNT. Two independent experiments were performed, and representative binding and neutralization curves are shown, with error bars representing mean ± SD binding was measured using a virus ELISA and neutralization was measured using a FRNT. Both ELISA and FRNT were performed in triplicate, and curves and IC50 or EC50 binding values were obtained using non-linear fit analysis with top of curve constrained to 100 for neutralization, using Prism software version 7 (GraphPad Software).