Extended Data Figure 9: Assembly activity strength during the social memory discrimination task.
a) Distribution of assembly social gain values from different regions. Assembly social gain defined as mean assembly strength during exploration within interaction zone divided by mean assembly strength during exploration outside interaction zone. Social gain was significantly greater than 1 for CA1 (P < 10−6, sign-rank test) and CA2 (P < 10−19) but not CA3 (P > 0.05). b) Left pair of bars: socially-related assembly strength = ([assembly strength inside social interaction zone minus strength outside social interaction zone]/[sum of strengths]) for social discriminant and non-discriminant assemblies (P < 10−3, rank-sum test). Right pair of bars: normalized social discrimination assembly strength (difference between assembly strength during interaction with preferred mouse minus the strength during the interaction with the other mouse divided by the sum of these two strengths) was greater for discriminant compared to non-discriminant assemblies (P < 10−8). c) Discriminant assemblies were reactivated during recall trial significantly more strongly than non-discriminant ones (P = 0.0421). Average peri-SWR activation of discriminant and non-discriminant assemblies in different hippocampal regions are shown in d) CA1: n = 116, P = 0.0252, e) CA2: n = 213, P =0.0144 and f) CA3: n = 59, P > 0.05.