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. Author manuscript; available in PMC: 2021 Nov 12.
Published in final edited form as: J Med Chem. 2020 Sep 10;63(21):12137–12155. doi: 10.1021/acs.jmedchem.0c00724

Figure 1.

Figure 1.

(A) The tetrahydro-diphenyl skeleton of CBD in the context of the base structures of three other main classes of cannabinoids (dibenzopyranes, benzopyranes, and acyclic prenyl-olivetols); as well as (B) five principal structural variations that occur in all cannabinoid classes. Different combinations of these four classes, with variations such as these presented as well as additional redox-driven metabolic modifications, explain why CBD and THC are just two molecules within the complex metabolome of cannabinoids.