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. Author manuscript; available in PMC: 2021 Nov 12.
Published in final edited form as: J Med Chem. 2020 Sep 10;63(21):12137–12155. doi: 10.1021/acs.jmedchem.0c00724

Figure 3.

Figure 3.

The axial hydrogen, H-4”ax, is involved not only in multiple J-coupling within the monoterpene moiety, but its 1H NMR resonance is also affected by the close resonance behavior of its coupling partners. The resulting pronounced higher order effects of the ddddddq-type multiplet encode the spin parameters of half of the molecule in such a way that the H-4”ax resonance alone becomes diagnostic for the entire CBD molecule. See S1, Supporting Information, for the detailed results of the underlying 1H iterative Full Spin Analysis (HiFSA).