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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Hypertension. 2020 Nov 2;76(6):1744–1752. doi: 10.1161/HYPERTENSIONAHA.120.15435

Figure 3: miR-133a downregulates target gene AGT expression in renal cortex.

Figure 3:

A) Schematic diagram showing the putative miR-133a binding sites within the 3’-untraslated region (3’UTR) of AGT; coding sequence (CD), and microRNA response element (MRE). B) AGT mRNA expression was measured by RT-PCR after intrarenal injection of either miR-133a (~2 × 108 TU) or scramble control into both kidneys of mice given LS for 7 days. C) miR-133a expression was measured after mice were given NS (−) or LS for 7 days. D) miR-133a expression was measured after mice were given NS (−) or HS for 7 days. E) AGT mRNA expression was determined after intrarenal injection of either miR-133a or scramble control into both kidneys of mice given HS for 7 days. Data are shown as mean ± SE; (n=10).