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. Author manuscript; available in PMC: 2020 Nov 14.
Published in final edited form as: J Med Chem. 2020 Oct 29;63(21):12786–12798. doi: 10.1021/acs.jmedchem.0c01173

Figure 1. Conserved pharmacophore binding in the ATP site of protein kinases.

Figure 1.

(A) The structures of 1 and 2, denoted 6 and 27 respectively in the original studies. (B) A summary of the analysis of the established ligands that bind to Ser/Thr protein kinases (EC number 2.7.11.1) or CK2α in the ATP site. (C) The structures of the four CK2α inhibitors and their protein-bound crystal structures which contain a benzoic acid group that binds in the ATP site46,48,56,59