Table 4.
Post-hoc effects of age, sex and NART-IQ on the isotropic signal fraction (ISOSF).
| Effect | Side | ROI | F(1,119)-value | pBHadj |
|---|---|---|---|---|
| Age | Left | Accumbens | 16.946 | < 0.001 |
| Amygdala | 0.002 | 0.977 | ||
| Caudate | 2.906 | 0.174 | ||
| Hippocampus | 32.296 | < 0.001 | ||
| Pallidum | 0.741 | 0.544 | ||
| Putamen | 3.705 | 0.121 | ||
| Thalamus | 17.881 | < 0.001 | ||
| Right | Accumbens | 8.272 | 0.016 | |
| Amygdala | 0.090 | 0.847 | ||
| Caudate | 4.359 | 0.090 | ||
| Hippocampus | 20.305 | < 0.001 | ||
| Pallidum | 0.168 | 0.787 | ||
| Putamen | 6.089 | 0.039 | ||
| Thalamus | 21.716 | < 0.001 | ||
| Left | Banks of superior temporal sulcus | 12.121 | 0.003 | |
| Caudal anterior cingulate | 12.152 | 0.004 | ||
| Cuneus | 17.203 | < 0.001 | ||
| Entorhinal | 0.170 | 0.788 | ||
| Frontal pole | 0.667 | 0.559 | ||
| Fusiform | 0.884 | 0.494 | ||
| Inferior parietal | 6.381 | 0.035 | ||
| Inferior temporal | 0.765 | 0.538 | ||
| Insula | 17.457 | < 0.001 | ||
| Lateral occipital | 6.671 | 0.031 | ||
| Lateral orbito frontal | 3.029 | 0.163 | ||
| Lingual | 2.481 | 0.212 | ||
| Medial orbito frontal | 6.335 | 0.035 | ||
| Middle temporal | 11.334 | 0.004 | ||
| Paracentral | 4.216 | 0.095 | ||
| Parahippocampal | 0.125 | 0.819 | ||
| Pars opercularis | 19.568 | < 0.001 | ||
| Pars orbitalis | 0.005 | 0.961 | ||
| Pars triangularis | 15.445 | < 0.001 | ||
| Postcentral | 14.471 | < 0.001 | ||
| Posterior cingulate | 15.798 | < 0.001 | ||
| Precentral | 5.314 | 0.057 | ||
| Precuneus | 19.354 | < 0.001 | ||
| Rostral anterior cingulate | 16.241 | < 0.001 | ||
| Rostral middle frontal | 5.017 | 0.067 | ||
| Superior frontal | 1.173 | 0.410 | ||
| Superior parietal | 0.963 | 0.470 | ||
| Superior temporal | 25.891 | < 0.001 | ||
| Supramarginal | 16.621 | < 0.001 | ||
| Temporal pole | 1.219 | 0.410 | ||
| Transverse temporal | 51.576 | < 0.001 | ||
| Right | Banks of superior temporal sulcus | 12.346 | 0.003 | |
| Caudal anterior cingulate | 7.267 | 0.025 | ||
| Cuneus | 13.388 | < 0.001 | ||
| Entorhinal | 0.131 | 0.819 | ||
| Frontal pole | 1.185 | 0.414 | ||
| Fusiform | 0.108 | 0.835 | ||
| Inferior parietal | 1.881 | 0.297 | ||
| Inferior temporal | 1.475 | 0.366 | ||
| Insula | 14.803 | < 0.001 | ||
| Isthmus cingulate | 6.659 | 0.031 | ||
| Lateral occipital | 1.818 | 0.307 | ||
| Lateral orbito frontal | 1.286 | 0.406 | ||
| Lingual | 7.195 | 0.024 | ||
| Medial orbito frontal | 3.288 | 0.147 | ||
| Middle temporal | 3.039 | 0.165 | ||
| Paracentral | 0.702 | 0.556 | ||
| PARAHIPPOCAMPAL | 1.158 | 0.412 | ||
| Pars opercularis | 15.415 | < 0.001 | ||
| Pars orbitalis | 2.665 | 0.195 | ||
| Pars triangularis | 0.523 | 0.605 | ||
| Pericalcerine | 16.505 | < 0.001 | ||
| Postcentral | 6.318 | 0.034 | ||
| Posterior cingulate | 18.89 | < 0.001 | ||
| Precentral | 4.015 | 0.104 | ||
| Precuneus | 15.968 | < 0.001 | ||
| Rostral anterior cingulate | 12.476 | 0.003 | ||
| Rostral middle frontal | 2.466 | 0.212 | ||
| Superior frontal | 0.676 | 0.550 | ||
| Superior parietal | 3.634 | 0.124 | ||
| Superior temporal | 12.296 | 0.003 | ||
| Supramarginal | 8.563 | 0.013 | ||
| Temporal pole | 2.727 | 0.189 | ||
| Transverse temporal | 44.346 | < 0.001 | ||
| Sex | Left | Accumbens | 4.687 | 0.078 |
| Amygdala | 0.320 | 0.693 | ||
| Caudate | 6.885 | 0.029 | ||
| Hippocampus | 30.457 | < 0.001 | ||
| Pallidum | 3.735 | 0.120 | ||
| Putamen | 0.886 | 0.497 | ||
| Thalamus | 6.685 | 0.031 | ||
| Right | Accumbens | 10.982 | 0.003 | |
| Amygdala | 3.110 | 0.161 | ||
| Caudate | 8.610 | 0.013 | ||
| Hippocampus | 37.739 | < 0.001 | ||
| Pallidum | 1.177 | 0.412 | ||
| Putamen | 0.595 | 0.577 | ||
| Thalamus | 28.188 | < 0.001 | ||
| Left | Banks of superior temporal sulcus | 9.745 | 0.007 | |
| Caudal anterior cingulate | 10.321 | 0.007 | ||
| Cuneus | 14.189 | < 0.001 | ||
| Entorhinal | 2.097 | 0.263 | ||
| Frontal pole | 1.317 | 0.400 | ||
| Fusiform | 0.471 | 0.621 | ||
| Inferior parietal | 19.193 | < 0.001 | ||
| Inferior temporal | 3.546 | 0.129 | ||
| Insula | 14.093 | < 0.001 | ||
| Lateral occipital | 15.940 | < 0.001 | ||
| Lateral orbito frontal | 0.039 | 0.902 | ||
| Lingual | 1.178 | 0.414 | ||
| Medial orbito frontal | 3.411 | 0.138 | ||
| Middle temporal | 17.995 | < 0.001 | ||
| Paracentral | 1.542 | 0.355 | ||
| Parahippocampal | 14.537 | < 0.001 | ||
| Pars opercularis | 11.519 | 0.003 | ||
| Pars orbitalis | 0.167 | 0.784 | ||
| Pars triangularis | 16.204 | < 0.001 | ||
| Postcentral | 28.162 | < 0.001 | ||
| Posterior cingulate | 16.237 | < 0.001 | ||
| Precentral | 22.987 | < 0.001 | ||
| Precuneus | 13.571 | < 0.001 | ||
| Rostral anterior cingulate | 4.385 | 0.088 | ||
| Rostral middle frontal | 35.530 | < 0.001 | ||
| Superior frontal | 13.064 | < 0.001 | ||
| Superior parietal | 18.143 | < 0.001 | ||
| Superior temporal | 26.621 | < 0.001 | ||
| Supramarginal | 42.479 | < 0.001 | ||
| Temporal pole | 4.436 | 0.088 | ||
| Transverse temporal | 30.601 | < 0.001 | ||
| Right | Banks of superior temporal sulcus | 14.697 | < 0.001 | |
| Caudal anterior cingulate | 10.623 | 0.004 | ||
| Cuneus | 24.330 | < 0.001 | ||
| Entorhinal | 0.491 | 0.616 | ||
| Frontal pole | 0.684 | 0.557 | ||
| Fusiform | 3.168 | 0.158 | ||
| Inferior parietal | 6.885 | 0.030 | ||
| Inferior temporal | 3.105 | 0.162 | ||
| Insula | 4.265 | 0.094 | ||
| Isthmus cingulate | 0.601 | 0.578 | ||
| Lateral occipital | 10.275 | 0.006 | ||
| Lateral orbito frontal | 0.102 | 0.839 | ||
| Lingual | 7.981 | 0.019 | ||
| Medial orbito frontal | 3.038 | 0.166 | ||
| Middle temporal | 5.352 | 0.055 | ||
| Paracentral | 9.075 | 0.010 | ||
| Parahippocampal | 3.733 | 0.121 | ||
| Pars opercularis | 7.161 | 0.027 | ||
| Pars orbitalis | 3.870 | 0.112 | ||
| Pars triangularis | 5.958 | 0.042 | ||
| Pericalcerine | 14.080 | < 0.001 | ||
| Postcentral | 19.109 | < 0.001 | ||
| Posterior cingulate | 14.954 | < 0.001 | ||
| Precentral | 17.777 | < 0.001 | ||
| Precuneus | 13.291 | < 0.001 | ||
| Rostral anterior cingulate | 5.785 | 0.046 | ||
| Rostral middle frontal | 24.380 | < 0.001 | ||
| Superior frontal | 16.120 | < 0.001 | ||
| Superior parietal | 8.266 | 0.016 | ||
| Superior temporal | 16.902 | < 0.001 | ||
| Supramarginal | 16.983 | < 0.001 | ||
| Temporal pole | 0.330 | 0.691 | ||
| Transverse temporal | 37.792 | < 0.001 | ||
| NART-IQ | Left | Accumbens | 0.709 | 0.556 |
| Amygdala | 3.741 | 0.120 | ||
| Caudate | 0.016 | 0.932 | ||
| Hippocampus | 0.065 | 0.864 | ||
| Pallidum | 0.022 | 0.922 | ||
| Putamen | 1.221 | 0.411 | ||
| Thalamus | 0.000 | 0.995 | ||
| Right | Accumbens | 0.022 | 0.924 | |
| Amygdala | 1.266 | 0.410 | ||
| Caudate | 1.809 | 0.306 | ||
| Hippocampus | 0.067 | 0.866 | ||
| Pallidum | 0.206 | 0.764 | ||
| Putamen | 0.606 | 0.579 | ||
| Thalamus | 0.481 | 0.618 | ||
| Left | Banks of superior temporal sulcus | 6.816 | 0.029 | |
| Caudal anterior cingulate | 0.035 | 0.901 | ||
| Cuneus | 0.200 | 0.767 | ||
| Entorhinal | 0.343 | 0.684 | ||
| Frontal pole | 1.745 | 0.315 | ||
| Fusiform | 0.039 | 0.904 | ||
| Inferior parietal | 2.029 | 0.274 | ||
| Inferior temporal | 0.019 | 0.925 | ||
| Insula | 4.834 | 0.073 | ||
| Lateral occipital | 0.306 | 0.697 | ||
| Lateral orbito frontal | 0.037 | 0.901 | ||
| Lingual | 0.621 | 0.574 | ||
| Medial orbito frontal | 0.000 | 0.993 | ||
| Middle temporal | 0.402 | 0.655 | ||
| Paracentral | 0.199 | 0.764 | ||
| Parahippocampal | 0.010 | 0.943 | ||
| Pars opercularis | 0.207 | 0.768 | ||
| Pars orbitalis | 1.006 | 0.459 | ||
| Pars triangularis | 0.636 | 0.570 | ||
| Postcentral | 1.370 | 0.388 | ||
| Posterior cingulate | 1.243 | 0.411 | ||
| Precentral | 0.401 | 0.653 | ||
| Precuneus | 0.078 | 0.852 | ||
| Rostral anterior cingulate | 0.582 | 0.581 | ||
| Rostral middle frontal | 1.208 | 0.411 | ||
| Superior frontal | 1.224 | 0.414 | ||
| Superior parietal | 6.435 | 0.033 | ||
| Superior temporal | 0.266 | 0.724 | ||
| Supramarginal | 0.879 | 0.493 | ||
| Temporal pole | 0.084 | 0.849 | ||
| Transverse temporal | 2.832 | 0.180 | ||
| Right | Banks of superior temporal sulcus | 6.815 | 0.030 | |
| Caudal anterior cingulate | 0.530 | 0.605 | ||
| Cuneus | 2.829 | 0.179 | ||
| Entorhinal | 4.702 | 0.077 | ||
| Frontal pole | 1.644 | 0.332 | ||
| Fusiform | 2.222 | 0.246 | ||
| Inferior parietal | 2.952 | 0.170 | ||
| Inferior temporal | 0.001 | 0.987 | ||
| Insula | 0.090 | 0.843 | ||
| Isthmus cingulate | 1.257 | 0.409 | ||
| Lateral occipital | 0.126 | 0.821 | ||
| Lateral orbito frontal | 0.014 | 0.933 | ||
| Lingual | 5.866 | 0.044 | ||
| Medial orbito frontal | 0.318 | 0.692 | ||
| Middle temporal | 0.097 | 0.842 | ||
| Paracentral | 2.527 | 0.208 | ||
| Parahippocampal | 1.983 | 0.280 | ||
| Pars opercularis | 0.242 | 0.741 | ||
| Pars orbitalis | 0.050 | 0.888 | ||
| Pars triangularis | 0.502 | 0.613 | ||
| Pericalcerine | 2.623 | 0.198 | ||
| Postcentral | 1.806 | 0.306 | ||
| Posterior cingulate | 1.662 | 0.331 | ||
| Precentral | 0.685 | 0.559 | ||
| Precuneus | 2.629 | 0.197 | ||
| Rostral anterior cingulate | 0.453 | 0.628 | ||
| Rostral middle frontal | 0.394 | 0.653 | ||
| Superior frontal | 1.525 | 0.355 | ||
| Superior parietal | 4.186 | 0.096 | ||
| Superior temporal | 0.002 | 0.978 | ||
| Supramarginal | 1.407 | 0.381 | ||
| Temporal pole | 4.445 | 0.087 | ||
| Transverse temporal | 0.024 | 0.923 |
pBHadj, 5% False Discovery Rate Benjamini–Hochberg adjusted p value; ROI, Region of Interest. Significant results are highlighted in bold.