. 2020 Nov 13;10:19787. doi: 10.1038/s41598-020-75992-9

Table 6.

Post-hoc effects of age and sex on cortical thickness and subcortical volume measures.

Effect	Side	ROI	Index	F_(1,149)-value	p_BHadj
Age	Left	Accumbens	Vol_ICVadj	7.037	0.027
		Amygdala	Vol_ICVadj	3.360	0.146
		Caudate	Vol_ICVadj	0.073	0.873
		Hippocampus	Vol_ICVadj	12.023	0.004
		Pallidum	Vol_ICVadj	1.141	0.448
		Putamen	Vol_ICVadj	8.886	0.012
		Thalamus	Vol_ICVadj	26.144	< 0.001
	Right	Accumbens	Vol_ICVadj	4.944	0.071
		Amygdala	Vol_ICVadj	3.723	0.120
		Caudate	Vol_ICVadj	0.225	0.778
		Hippocampus	Vol_ICVadj	2.828	0.190
		Pallidum	Vol_ICVadj	2.444	0.221
		Putamen	Vol_ICVadj	7.722	0.021
		Thalamus	Vol_ICVadj	45.557	< 0.001
	Left	Banks of superior temporal sulcus	CT	5.798	0.047
		Caudal anterior cingulate	CT	0.583	0.589
		Caudal middle frontal	CT	8.485	0.016
		Cuneus	CT	3.911	0.110
		Entorhinal	CT	0.120	0.836
		Frontal pole	CT	0.076	0.885
		Fusiform	CT	5.474	0.057
		Inferior parietal	CT	11.874	0.004
		Inferior temporal	CT	7.261	0.027
		Insula	CT	20.522	< 0.001
		Isthmus cingulate	CT	0.130	0.836
		Lateral occipital	CT	4.536	0.086
		Lateral orbito frontal	CT	12.478	0.006
		Lingual	CT	6.891	0.030
		Medial orbito frontal	CT	7.171	0.026
		Middle temporal	CT	12.759	< 0.001
		Paracentral	CT	20.354	< 0.001
		Parahippocampal	CT	7.647	0.022
		Pars opercularis	CT	14.469	< 0.001
		Pars orbitalis	CT	18.893	< 0.001
		Pars triangularis	CT	19.089	< 0.001
		Pericalcerine	CT	2.678	0.203
		Postcentral	CT	12.426	0.006
		Posterior cingulate	CT	1.032	0.467
		Precentral	CT	28.246	< 0.001
		Precuneus	CT	12.353	0.006
		Rostral anterior cingulate	CT	7.759	0.022
		Rostral middle frontal	CT	13.280	< 0.001
		Superior frontal	CT	24.962	< 0.001
		Superior parietal	CT	9.821	0.009
		Superior temporal	CT	27.155	< 0.001
		Supramarginal	CT	22.159	< 0.001
		Temporal pole	CT	0.682	0.555
		Transverse temporal	CT	2.574	0.211
	Right	Banks of superior temporal sulcus	CT	11.955	0.006
		Caudal anterior cingulate	CT	3.192	0.150
		Caudal middle frontal	CT	2.576	0.209
		Cuneus	CT	1.553	0.363
		Entorhinal	CT	0.121	0.840
		Frontal pole	CT	0.015	0.938
		Fusiform	CT	18.048	< 0.001
		Inferior parietal	CT	22.640	< 0.001
		Inferior temporal	CT	9.714	0.008
		Insula	CT	12.353	0.005
		Isthmus cingulate	CT	4.464	0.088
		Lateral occipital	CT	4.184	0.099
		Lateral orbito frontal	CT	13.295	< 0.001
		Lingual	CT	7.316	0.026
		Medial orbito frontal	CT	6.738	0.029
		Middle temporal	CT	18.517	< 0.001
Paracentral		CT	17.110	< 0.001
Parahippocampal		CT	8.659	0.015
Pars opercularis		CT	12.395	0.005
Pars orbitalis		CT	12.59	0.005
Pars triangularis		CT	19.087	< 0.001
Pericalcerine		CT	2.454	0.221
Postcentral		CT	7.200	0.025
Posterior cingulate		CT	6.381	0.038
Precentral		CT	10.001	0.009
Precuneus		CT	15.729	< 0.001
Rostral anterior cingulate		CT	1.949	0.290
Rostral middle frontal		CT	10.641	0.005
Superior frontal		CT	18.426	< 0.001
Superior parietal		CT	7.745	0.021
Superior temporal		CT	19.439	< 0.001
Supramarginal		CT	10.607	0.005
Temporal pole		CT	0.020	0.950
Transverse temporal		CT	1.548	0.359
Sex	Left	Accumbens	Vol_ICVadj	8.927	0.012
		Amygdala	Vol_ICVadj	0.074	0.878
		Caudate	Vol_ICVadj	4.492	0.086
		Hippocampus	Vol_ICVadj	10.913	0.007
		Pallidum	Vol_ICVadj	1.649	0.343
		Putamen	Vol_ICVadj	6.103	0.042
		Thalamus	Vol_ICVadj	1.934	0.289
	Right	Accumbens	Vol_ICVadj	3.833	0.113
		Amygdala	Vol_ICVadj	0.513	0.623
		Caudate	Vol_ICVadj	7.183	0.025
		Hippocampus	Vol_ICVadj	4.695	0.080
		Pallidum	Vol_ICVadj	7.633	0.020
		Putamen	Vol_ICVadj	4.265	0.096
		Thalamus	Vol_ICVadj	4.360	0.090
	Left	Banks of superior temporal sulcus	CT	3.183	0.157
		Caudal anterior cingulate	CT	0.019	0.935
		Caudal middle frontal	CT	0.018	0.934
		Cuneus	CT	1.857	0.302
		Entorhinal	CT	0.075	0.881
		Frontal pole	CT	0.794	0.519
		Fusiform	CT	0.285	0.761
		Inferior parietal	CT	2.104	0.268
		Inferior temporal	CT	0.229	0.780
		Insula	CT	9.485	0.008
		Isthmus cingulate	CT	0.031	0.928
		Lateral occipital	CT	0.244	0.772
		Lateral orbito frontal	CT	0.058	0.886
		Lingual	CT	0.891	0.503
		Medial orbito frontal	CT	1.146	0.455
		Middle temporal	CT	0.206	0.783
		Paracentral	CT	2.266	0.244
		Parahippocampal	CT	0.936	0.490
		Pars opercularis	CT	1.245	0.436
		Pars orbitalis	CT	0.134	0.837
		Pars triangularis	CT	2.647	0.204
		Pericalcerine	CT	0.202	0.782
		Postcentral	CT	4.122	0.100
		Posterior cingulate	CT	0.295	0.759
		Precentral	CT	0.008	0.948
		Precuneus	CT	0.098	0.859
		Rostral anterior cingulate	CT	0.038	0.917
		Rostral middle frontal	CT	0.019	0.941
		Superior frontal	CT	1.171	0.451
		Superior parietal	CT	0.459	0.649
		Superior temporal	CT	0.141	0.835
		Supramarginal	CT	4.028	0.105
		Temporal pole	CT	1.133	0.447
		Transverse temporal	CT	1.466	0.377
	Right	Banks of superior temporal sulcus	CT	3.084	0.166
		Caudal anterior cingulate	CT	0.069	0.872
		Caudal middle frontal	CT	0.809	0.527
		Cuneus	CT	0.855	0.513
		Entorhinal	CT	0.746	0.536
		Frontal pole	CT	1.243	0.433
		Fusiform	CT	0.799	0.522
		Inferior parietal	CT	5.173	0.063
		Inferior temporal	CT	0.019	0.946
		Insula	CT	5.346	0.059
		Isthmus cingulate	CT	6.254	0.037
		Lateral occipital	CT	0.625	0.574
		Lateral orbito frontal	CT	2.769	0.193
		Lingual	CT	0.267	0.770
		Medial orbito frontal	CT	0.941	0.493
		Middle temporal	CT	0.167	0.811
Paracentral		CT	2.089	0.267
Parahippocampal		CT	1.127	0.444
Pars opercularis		CT	0.993	0.478
Pars orbitalis		CT	0.670	0.556
Pars triangularis		CT	0.007	0.944
Pericalcerine		CT	0.008	0.959
Postcentral		CT	2.954	0.178
Posterior cingulate		CT	0.704	0.550
Precentral		CT	0.252	0.771
Precuneus		CT	0.806	0.524
Rostral anterior cingulate		CT	1.115	0.444
Rostral middle frontal		CT	0.008	0.953
Superior frontal		CT	0.003	0.959
Superior parietal		CT	4.903	0.072
Superior temporal		CT	0.220	0.777
Supramarginal		CT	1.145	0.451
Temporal pole		CT	0.005	0.951
Transverse temporal		CT	0.262	0.768

CT cortical thickness; Vol_ICVadj volume adjusted for intracranial volume. p_BHadj, 5% False Discovery Rate Benjamini–Hochberg adjusted p value; ROI region of interest.