. 2020 Nov 13;10:19763. doi: 10.1038/s41598-020-75681-7

Table 2.

Summary of the results obtained in a blind study of detection of CWD prions in blood from white-tailed deer coding for different polymorphic versions of the prion protein (at position 96).

Biological sample	96GG^b	96GS	96SS
Late Pre-symptomatic WTD (B+ LN+)	47/49 95.9%	7/12 58.3%	ns^c
Early pre-symptomatic WTD (B− LN+)	18/34 52.9%	8/14 57.1%	1/5 20.0%
Negative WTD (B− LN−)	0/10 100%	0/8 100%	0/3 100%
Overall correct diagnosis^a	80.6%^d,e	67.6%^f,g	50%^h,i

Biological sample

96GG^b

96GS

96SS

Late Pre-symptomatic WTD

(B+ LN+)

47/49

95.9%

7/12

58.3%

ns^c

Early pre-symptomatic WTD

(B− LN+)

18/34

52.9%

8/14

57.1%

1/5

20.0%

Negative WTD

(B− LN−)

0/10

100%

0/8

100%

0/3

100%

Overall correct diagnosis^a

80.6%^d,e

67.6%^f,g

50%^h,i

^aSamples were declared positive if at least one of the two replicates performed provided a protease-resistant PrP^Sc signal in the PMCA assay.

^bData from Kramm et al.¹².

^cns no samples.

^dEstimates of sensitivity for the PrP 96GG group, with 95% confidence intervals: 67.9–86.8%.

^eEstimates of specificity for the PrP 96GG group, with 95% confidence intervals: 69.2–100%.

^fEstimates of sensitivity for the PrP 96GS group, with 95% confidence intervals: 29.9–70.1%.

^gEstimates of specificity for the PrP 96GS group, with 95% confidence intervals: 63.1–100%.

^hEstimates of sensitivity for the PrP 96SS group, with 95% confidence intervals: 0.5–71.6%.

ⁱEstimates of specificity for the PrP 96SS group, with 95% confidence intervals: 29.2–100%.