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. 2020 Nov 13;10:19769. doi: 10.1038/s41598-020-76794-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative MRI of each of 3 age-matched mutation carriers and non-carriers. Coded in the order of scale of medial temporal atrophy, posterior atrophy (PA) and white matter hyperintensity (WMH), from left to right in mutation carriers are (4,3,0), (2,1,0) and (1,2,0) and non-carriers are (1,1,1), (1,1,2) and (3,0,2). Various degree of MTA was noted across patients with or without mutation; in the contrary, WMH was seen predominantly in non-mutation carriers.