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. 2020 Nov 13;3:672. doi: 10.1038/s42003-020-01397-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — (a) Schematic representation of the PIRB receptor. The cytoplasmic region with four ITIM repeats spans approximately 190 residues. (b) Western detection of the HACS1-PIRB interaction. A pulldown was performed with immobilized HACS1 SH3 domain fragments fused to maltose-binding protein (MBP) and extracts of mouse bone marrow (BM) or spleen. Chemiluminescent detection of PIRB was achieved with a mouse anti-PIRB antibody.