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. 2020 Nov 13;3:678. doi: 10.1038/s42003-020-01411-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Volcano plots showing the log-fold transcriptional changes to RV (x-axis) in controls (A) and cases (B) at FDR < 0.05 (dashed horizontal line). C The log fold change in the 1929 genes that are differentially expressed in both cases (x-axis) and controls (y-axis). Gray points indicate genes with greater log fold change in controls; burgundy points indicate genes with greater log fold change in cases. Arrows point to black dots representing the thirteen genes with opposite direction of effect in cases and controls.