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. 2020 Nov 13;3:678. doi: 10.1038/s42003-020-01411-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The numbers of RV-responsive genes, chromatin regions, or pcHi-C target genes of RV-responsive chromatin regions in controls (gray) and cases (burgundy) and both (white) are shown in the first three columns. The last column shows the number the pcHi-C predicted genes where the chromatin accessible and gene expression were correlated (Spearman’s correlation, FDR adj. p < 0.05). B The promoter of PLAUR loops to an area of open chromatin at chr19:43967179–43968550. Chromatin accessibility for each condition is shown in the top panel, gene expression in the second panel and the bottom panel indicates pcHi-C looping from the PLAUR promoter. The pink box indicates the PLAUR promoter, the blue box indicates the RV-responsive area of open chromatin. C Correlation between expression of PLAUR and chromatin accessibility at chr19:43967179–43968550. D, E are gene-chromatin pairs where the gene is RV-responsive in both cases and controls while the chromatin is only RV-responsive in the controls.