Fig. 4. Inbreeding depression in genomic windows.

ID was measured in 1000 three Mb-wide non-overlapping sliding windows along the genome; the p-value threshold was corrected by Bonferroni and set at < 1 × 10⁻⁰⁵. a Inbreeding depression on body mass index (BMI) for men. A window on chromosome 14 (position 63-66 Mb) was highly significant. 23 protein coding genes were found in this window as shown in Table S5. Two SNPs located in this window, in KCNH5 and FUT8, were associated with BMI in GWAS studies. b Inbreeding depression on visceral adipose tissue (VAT) for women. Two windows on chromosomes 2 (position 0-3 Mb) and 4 (position 57-60 Mb) were significant. 9 protein coding genes were found in the chromosome 2 window and 2 on chromosome 4 (Supplementary Table 4). No GWAS hits related to this trait have been reported in these regions of chromosome 2 and 4.