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. 2020 Nov 13;10:19815. doi: 10.1038/s41598-020-76756-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier analyses of mCRC samples based on DpR. (A) OS in all patients receiving chemotherapy plus cetuximab or bevacizumab; (B) OS in patients with left-sided mCRCs receiving chemotherapy plus cetuximab; (C) OS in patients with left-sided mCRCs receiving chemotherapy plus bevacizumab; (D) OS in patients with right-sided mCRCs receiving chemotherapy plus cetuximab; and (E) OS in patients with right-sided mCRCs receiving chemotherapy plus bevacizumab. Median DpRs were calculated as -30 for A, -32 for B and C, and -27.5 for D and E, respectively. CI confidence interval, HR hazard ratio. Broken line, all population.