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. 2020 Nov 13;3:677. doi: 10.1038/s42003-020-01404-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Expression of ET_AR, ZEB1, N-cadherin, Vimentin, and E-cadherin in ovarian cancer cell lines analyzed by Western blotting (WB). β-actin is used as loading control. b Correlation of the ET_AR and ZEB1 expression in the indicated cell lines. The ratio of ET_AR/β-actin and ZEB1/β-actin, evaluated by WB as shown in a, is presented as bar and line, respectively. Values are the mean ± SD (n = 3). c Boxplot diagrams of EDNRA (ET_AR) and ZEB1 gene expression in HG-SOC patients from TCGA, subdivided in four molecular subtypes. d Kaplan–Meier curves of overall survival (OS) of 352 patients from TCGA grouped in high EDNRA/ZEB1 levels (160 patients, z-score > 1.5, red line) and low EDNRA/ZEB1 expression levels (192 patients, z-score < 1.5, blue line). e Kaplan–Meier curves of progression-free survival (PFS) of 303 patients from TCGA subdivided in high levels of EDNRA/ZEB1 expression (135 patients, z-score > 1.5, red line) and low levels of EDNRA/ZEB1 (168 patients, z-score < 1.5, blue line).