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. 2020 Nov 13;10:140. doi: 10.1186/s13550-020-00721-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The averaged [¹¹C]UCB-J PET V_T(IDIF) maps superimposed on a mouse MR template at 3 and 9 mo for both genotypes, b combined with the corresponding averaged [¹¹C]UCB-J PET V_T(IDIF) values ± SD. Young adult Sapap3 ko mice are characterized by a lower synaptic density availability in the cortex, the striatum, the thalamus, and the hippocampus when compared to their wt counterparts. Also, both genotypes show a progressive decline in synaptic density availability with ageing, which was more pronounced in the wt controls. The corresponding averaged values ± SD can be consulted in Additional file 1: Table 1. (ko, knockout; mo, months; MR, magnetic resonance; wt, wildtype; V_T(IDIF), volume-of-distribution; *p < 0.05, **p < 0.01, ***p < 0.001)