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. 2020 Nov 13;10:140. doi: 10.1186/s13550-020-00721-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The results of the voxel-based statistical parametric mapping analysis of the [¹¹C]UCB-J V_T(IDIF) maps. a A representation of all analysed brain regions on a corresponding MR template. b Hypo T-map showing all voxel clusters (threshold: 100 voxels) with a significantly (p < 0.01) lower V_T(IDIF) in ko compared to wt mice at the age of 3 mo. c Hypo T-maps indicating all voxel clusters (threshold: 100 voxels) that significantly (p < 0.01) declined over time in wt mice. d Similar hypo T-maps as in panel c for the ko mice (ctx = cortex; hc = hippocampus; ko = knockout; mo = months; MR = magnetic resonance; str = striatum; th = thalamus; wt = wildtype)