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. 2020 Jul 22;31(4):392–400. doi: 10.1007/s12022-020-09640-3

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© The Author(s) 2020

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Fig. 3 — Patients with Merkel cell carcinomas expressing MCPyV show a better survival than patients with MCPyV-negative carcinomas (a). MCPyV immunoreactivity is nuclear (b). Image (c) is an example of a MCPyV-negative Merkel cell carcinoma. Expression of p63 by neoplastic cells is associated with a worse prognosis (d). In image (e), there is an example of p63-negative Merkel cell carcinoma. Note the internal control in the basal layer of the normal epidermis. p63 is expressed in the nuclei of cancerous cells (f)