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. 2020 Sep 30;42(5):589–605. doi: 10.1007/s00281-020-00814-z

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© The Author(s) 2020

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Fig. 2 — The age-related microbiota changes (dysbiosis) at each body site. Dysbiosis may contribute to inflammaging because long-term stimulation of IS may cause immunosenescence. Such inflammatory state might make the host more sensitive to bacteria, and in turn, alterations in the composition of microbiota are associated with the progression of various pathological conditions in older adults [19]