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. 2020 Aug 11;22(6):1511–1522. doi: 10.1007/s11307-020-01522-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5. — a Representative color, NIRF, and merged images of CH88.2-800CW binding specificity in a HT-29 tumor-bearing mouse model using the clinical Artemis NIR imaging system at 150-ms exposure. Regions of interest were selected in similar fashion to the Pearl as shown by the red and blue shapes, corresponding to the tumor and background area, respectively (only displayed in the left figure). To allow better visualization of the field of interest, the tumor-bearing skin was manually mobilized to the center of the camera’s optical field as is displayed by left and right back images. b Representative images of CH88.2-800CW binding specificity in a BxPC-3 tumor-bearing mouse model.