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. 2020 Aug 11;22(6):1511–1522. doi: 10.1007/s11307-020-01522-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6. — a Representative examples of ex vivo hematoxylin-eosin (HE) staining, NIR fluorescence heatmap (800 nm), and FG88.2 staining on HT-29 and BxPC-3 tumor tissue sections. Overview images are taken at × 25 magnification and inserts at × 100 magnification. Scale bars represent 500 μm and 100 μm for overview and insert images, respectively. b Average tumor-to-liver, tumor-to-colon, and tumor-to-pancreas ratios in HT-29 and BxPC-3 tumor-bearing mice at 168 h/1 week post-injection. c Biodistribution of CH88.2-800CW at 168h/1week post-injection expressed as tumor or organ MFI. d Ex vivo fluorescent images of resected tumors and organs. Sk, skin; Hrt, heart; Lu, lungs; Li, liver; St, stomach; Sp, spleen; Pa, pancreas; Du, duodenum; Co, colon; Ki, kidneys; Mu, muscle; Tu, tumors (under brackets); Br, brain.