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. 2020 Sep 12;140(6):863–879. doi: 10.1007/s00401-020-02224-9

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© The Author(s) 2020, corrected publication 2020

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Fig. 3 — Differential methylation signature is unique to sCJD and to blood. a DNA methylation levels (%) at each DMPs chosen for replication by pyrosequencing sCJD patients (purple) and controls (orange). Labels above each plot show genomic coordinates and overlapping genes. b DNA methylation levels (%) at CpG sites adjacent to DMPs in sCJD patients (purple) and controls (orange). Labels above each plot show genomic coordinates and overlapping genes. c DNA methylation (%) at replicated DMPs in Alzheimer’s disease (grey), iatrogenic CJD (brown) and inherited prion disease patients (green) compared to controls (orange). d Methylation at replicated sites in frontal cortex-derived DNA from sCJD patients (purple) and non-demented controls (orange). See Supplementary Table 3, online resource, for all p values. p value < 0.05 (*); p value < 0.01 (**); p value < 0.001 (***); p value < 0.0001 (****)