Table 1.
Sample characteristics of the individuals included in the analyses
| Study stage | Group | N | Average age (range) | Sex (% F) | Codon 129 (%) MM:MV:VV |
Average MRC Scale score (range) |
|---|---|---|---|---|---|---|
| Exploratory | sCJD | 114 | 67.6 (49–85) | 50.9 | 46:22:32 | 6.3 (0–20) |
| Control | 106 | 69.3 (41–83) | 55.7 | 44:43:13 | 20 | |
| Replication | sCJD | 72 | 67.3 (26–86) | 58.3 | 54:23:23 | 4.5 (0–18) |
| Control | 114 | 78.2 (61–93) | 64.9 | Unknown | 20 | |
| Specificity | Control | 114 | 78.2 (61–93) | 64.9 | Unknown | 20 |
| AD | 60 | 72.8 (70–77) | 56.7 | Unknown | Unknown | |
| iCJD | 18 | 46.4 (41–53) | 11.1 | 27:73:00 | 10.3 (0–18) | |
| IPD | 11 | 46.0 (39–68) | 45.4 | 64:36:00 | 17.0 (8–20) | |
| Brain | sCJD | 51 | 59.2 (38–87) | 41.2 | 65:10:25 | 0 |
| Control | 33 | 74.0 (41–89) | 54.2 | Unknown | 0 |
sCJD sporadic CJD, AD Alzheimer’s disease, iCJD iatrogenic CJD, IPD inherited prion disease