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. 2020 Sep 14;140(6):893–906. doi: 10.1007/s00401-020-02218-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Heatmap of paragangliomas of various locations. Unsupervised hierarchical clustering based on the 10.000 most differentially methylated CpG sites clearly separates CEP from other paragangliomas. Furthermore, TCGA subclusters within paragangliomas of thoraco-abdominal and adrenal origin is recapitulated (M1-M3 cluster). NH-PGLs form a separate subcluster close to M1 hypermethylated cases within PGLs