Fig. 1.

The coarse-grained plaque and its localization. a The coarse-grained plaque was defined using Aβ immunohistochemistry (aa 8-17; 6F/3D) by its size (30–100 µm), coarse-grainy deposits with the appearance of multiple cores, Aβ-devoid pores, and a vague rim. Tubular-like structures (arrowhead) were seen within the plaque. b The coarse-grained plaque was predominantly found in layers II–IV of sulcal fundi and c near CAA-affected vessels. Scale bar is applicable to all images and represents 10 µm in a, 400 µm in b, and 200 µm in c. Aβ amyloid-beta, CAA cerebral amyloid angiopathy