Fig. 10.

3D composition of neuroinflammation and vascular attribution in the coarse-grained plaque. Representative CLSM 3D images are shown for neuroinflammation (top row) and vascular attribution (bottom row) in and near the coarse-grained plaque. CD68 or GFAP immunoreactivity was found throughout the coarse-grained plaque (top row). Most coarse-grained plaques were in direct contact with a vessel, which appeared as a string vessel for this particular plaque. White cross in XY indicates the same point in space as the white cross in XZ and YZ. Scale bar represents 10 µm and is applicable to all images. Aβ amyloid-beta, CLSM confocal laser scanning microscopy