Fig. 11.

Hypothetical illustration of the coarse-grained plaque’s origin. This figure illustrates the coarse-grained plaques’ similarities and differences with the two other forms of Aβ deposits, being parenchymal plaques illustrated by the classic cored plaque and vascular-located Aβ illustrated by CAA. We placed the coarse-grained plaque in-between parenchymal and vascular aggregates, based on its parenchymal perivascular localization, microglial activation, Aβ₄₀ predominance and norrin immunoreactivity. See “Discussion” section for explanation. Aβ amyloid-beta, Aβ₄₀ amyloid-beta 40, Aβ₄₂ amyloid-beta 42, CAA cerebral amyloid angiopathy